HIV and antiretroviral therapy-related fat alterations

JR Koethe, C Lagathu, JE Lake, P Domingo… - Nature reviews Disease …, 2020 - nature.com
Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …

Weight gain and integrase inhibitors

AR Eckard, GA McComsey - Current opinion in infectious diseases, 2020 - journals.lww.com
Although INSTI-based regimens are highly efficacious for viral suppression, they appear to
cause more weight gain and treatment emergent obesity than non-INSTI-based regimens …

Weight gain following initiation of antiretroviral therapy: risk factors in randomized comparative clinical trials

PE Sax, KM Erlandson, JE Lake… - Clinical Infectious …, 2020 - academic.oup.com
Background Initiation of antiretroviral therapy (ART) often leads to weight gain. While some
of this weight gain may be an appropriate return-to-health effect, excessive increases in …

Greater weight gain in treatment-naive persons starting dolutegravir-based antiretroviral therapy

K Bourgi, PF Rebeiro, M Turner… - Clinical Infectious …, 2020 - academic.oup.com
Background Recent studies have reported weight gain in virologically suppressed persons
living with human immunodeficiency virus (PLWH) switched from older antiretroviral therapy …

Weight gain among treatment‐naïve persons with HIV starting integrase inhibitors compared to non‐nucleoside reverse transcriptase inhibitors or protease inhibitors …

K Bourgi, CA Jenkins, PF Rebeiro… - Journal of the …, 2020 - Wiley Online Library
Introduction Weight gain following antiretroviral therapy (ART) initiation is common,
potentially predisposing some persons with HIV (PWH) to cardio‐metabolic disease. We …

Brief report: weight gain in persons with HIV switched from efavirenz-based to integrase strand transfer inhibitor–based regimens

J Norwood, M Turner, C Bofill, P Rebeiro… - JAIDS Journal of …, 2017 - journals.lww.com
Background: With the introduction of integrase strand transfer inhibitor (INSTI)-based
antiretroviral therapy, persons living with HIV have a potent new treatment option. Recently …

Differential mechanisms affecting weight loss and weight loss maintenance

M Rosenbaum, G Foster - Nature metabolism, 2023 - nature.com
In most lifestyle, pharmacological and surgical interventions, weight loss occurs over an
approximately 6-to 9-month period and is followed by a weight plateau and then weight …

Obesity and weight gain in persons with HIV

SS Bailin, CL Gabriel, CN Wanjalla… - Current HIV/AIDS Reports, 2020 - Springer
Abstract Purpose of Review The proportion of overweight and obese persons with HIV
(PWH) has increased since the introduction of antiretroviral therapy (ART). We aim to …

Obesity following ART initiation is common and influenced by both traditional and HIV-/ART-specific risk factors

DR Bakal, LE Coelho, PM Luz, JL Clark… - Journal of …, 2018 - academic.oup.com
Background Obesity rates are increasing among HIV-infected individuals, but risk factors for
obesity development on ART remain unclear. Objectives In a cohort of HIV-infected adults in …

The impact of weight gain during HIV treatment on risk of pre-diabetes, diabetes mellitus, cardiovascular disease, and mortality

S Kumar, K Samaras - Frontiers in endocrinology, 2018 - frontiersin.org
Since the introduction of combined antiretroviral therapy (cART) and more effective
treatments for AIDS, there has been a dramatic shift from the weight loss and wasting that …