Tumour-infiltrating lymphocytes: from prognosis to treatment selection
K Brummel, AL Eerkens, M de Bruyn… - British Journal of …, 2023 - nature.com
Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity.
Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we …
Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we …
The evolving role of tissue-resident memory T cells in infections and cancer
S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …
tissues. TRM form an integral part of the immune sensing network and have the ability to …
[HTML][HTML] Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer
B Virassamy, F Caramia, P Savas, S Sant, J Wang… - Cancer Cell, 2023 - cell.com
CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (T RM) cell phenotype
are associated with favorable prognosis in patients with triple-negative breast cancer …
are associated with favorable prognosis in patients with triple-negative breast cancer …
Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin
The immune system can suppress tumour development both by eliminating malignant cells
and by preventing the outgrowth and spread of cancer cells that resist eradication. Clinical …
and by preventing the outgrowth and spread of cancer cells that resist eradication. Clinical …
[HTML][HTML] Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment
Natural compounds are widely used to prevent and treat various diseases due to their
antioxidant and anti-inflammatory effects. As a kind of promising natural compound, plant …
antioxidant and anti-inflammatory effects. As a kind of promising natural compound, plant …
NKG2A blockade potentiates CD8 T cell immunity induced by cancer vaccines
N van Montfoort, L Borst, MJ Korrer, M Sluijter… - Cell, 2018 - cell.com
Tumor-infiltrating CD8 T cells were found to frequently express the inhibitory receptor
NKG2A, particularly in immune-reactive environments and after therapeutic cancer …
NKG2A, particularly in immune-reactive environments and after therapeutic cancer …
Tissue-resident memory T cells in breast cancer control and immunotherapy responses
The presence of tumour-infiltrating lymphocytes (TILs) is associated with favourable
outcomes in patients with breast cancer as well as in those with other solid tumours. T cells …
outcomes in patients with breast cancer as well as in those with other solid tumours. T cells …
Resident memory T cells, critical components in tumor immunology
F Mami-Chouaib, C Blanc, S Corgnac, S Hans… - … for immunotherapy of …, 2018 - Springer
CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic
approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A …
approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A …
Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
E Menares, F Gálvez-Cancino… - Nature …, 2019 - nature.com
Tissue-resident memory CD8+ T (Trm) cells mediate potent local innate and adaptive
immune responses and play a central role against solid tumors. However, whether Trm cells …
immune responses and play a central role against solid tumors. However, whether Trm cells …
Tissue-resident memory T cells at the center of immunity to solid tumors
Immune responses in tissues are constrained by the physiological properties of the tissue
involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T …
involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T …