Interaction between primary hyperlipidemias and type 2 diabetes: therapeutic implications
There is a gap of knowledge about the clinical and pathophysiological implications resulting
from the interaction between primary hyperlipidemias and type 2 diabetes (T2D). Most of the …
from the interaction between primary hyperlipidemias and type 2 diabetes (T2D). Most of the …
Causal associations between insulin and Lp (a) levels in Caucasian population: a Mendelian randomization study
M Lejawa, M Goławski, M Fronczek, T Osadnik… - Cardiovascular …, 2024 - Springer
Background Numerous observational studies have demonstrated that circulating lipoprotein
(a)[Lp (a)] might be inversely related to the risk of type 2 diabetes (T2D). However, recent …
(a)[Lp (a)] might be inversely related to the risk of type 2 diabetes (T2D). However, recent …
Do iron homeostasis biomarkers mediate the associations of liability to type 2 diabetes and glycemic traits in liver steatosis and cirrhosis: a two-step Mendelian …
Abstract Background Previous studies, including Mendelian randomization (MR), have
demonstrated type 2 diabetes (T2D) and glycemic traits are associated with increased risk of …
demonstrated type 2 diabetes (T2D) and glycemic traits are associated with increased risk of …
[HTML][HTML] The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and …
Background Selenium has potential safeguarding properties against cognitive decline,
because of its role in protecting DNA, proteins, and lipids in the brain from oxidative …
because of its role in protecting DNA, proteins, and lipids in the brain from oxidative …
Drug-target Mendelian randomisation applied to metabolic dysfunction-associated steatotic liver disease: opportunities and challenges
S Luo, MH Zheng, VWS Wong… - …, 2024 - egastroenterology.bmj.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most
prevalent cause of chronic liver disease worldwide affecting over one-third of the adult …
prevalent cause of chronic liver disease worldwide affecting over one-third of the adult …
Multi-omics characterization of type 2 diabetes associated genetic variation
Discerning the mechanisms driving type 2 diabetes (T2D) pathophysiology from genome-
wide association studies (GWAS) remains a challenge. To this end, we integrated omics …
wide association studies (GWAS) remains a challenge. To this end, we integrated omics …
Causal association of circulating metabolites with diabetic retinopathy: a bidirectional Mendelian randomization analysis
B Li, X Zhao, W **e, Z Hong, Y Cao, Y Ding… - Frontiers in …, 2024 - frontiersin.org
Introduction The retina is a highly metabolically active tissue, and there is a lack of clarity
about the relationship between metabolites and diabetic retinopathy (DR). This study used …
about the relationship between metabolites and diabetic retinopathy (DR). This study used …
Identification of distinct trajectories in preclinical type 2 diabetes and their associations with outcomes
Abstract Type 2 Diabetes Mellitus (T2DM) is increasingly prevalent and significantly impacts
patients' lives. However, the phenotypic and genetic heterogeneity of the preclinical stage of …
patients' lives. However, the phenotypic and genetic heterogeneity of the preclinical stage of …
Exploring the Effect of Different Glycemic Traits and Antidiabetic Drug Targets on Biological Aging
S Wang, P Wang, Q Wang, X Chen, S Lu - Available at SSRN 5016425 - papers.ssrn.com
Background: Individuals who share the same chronological age may exhibit differing
susceptibility to aging-related diseases or mortality risks due to differences in biological …
susceptibility to aging-related diseases or mortality risks due to differences in biological …