Eutectic mixtures have been known for a long time in the pharmaceutical field. However, its
potential as a system to improve the solubility and dissolution of poorly water-soluble drugs …

Cocrystals have been extensively used to improve the physicochemical properties and
bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis …

Gallic acid (GA) is a naturally occurring polyphenolic compound exhibiting anti-tumor
activity. To clarify the capability of GA in optimizing the in vitro/in vivo properties of the first …

Fast dissolution of nonsteroidal anti-inflammatory drugs (NSAIDs) is a prerequisite from
patient perspective. However, most NSAIDs are slowly dissolving acidic compounds …

Berberine (BBR) exerts specific therapeutic effects on various diseases such as diabetes,
obesity, and other inflammation-associated diseases. However, the low oral bioavailability …

The aim of present work was to explore the temperature-composition phase diagram for
detection of formation of a multi-component system. Fusion of model drug Nimesulide (NIM) …

Cocrystallization of the antituberculosis drug pyrazinamide (PZA) with several substituted
aromatic carboxylic acids as coformers was studied. The combinations were analyzed by X …

Complexity and heterogeneous nature of most diseases have posed greater challenges in
the modern healthcare system. Fixed-dose combination can offer an ideal way to improve …

Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and
ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for …

To display the capability of the phenolic acid nutraceutical ferulic acid (FLA) in optimizing the
in vitro/in vivo properties of the antiviral drug amantadine hydrochloride (AMH) and achieve …