The worldwide obesity epidemic has emerged as a major cause of insulin resistance and
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Physical exercise is well known as a non-pharmacological and holistic therapy believed to
prevent and mitigate numerous neurological conditions and alleviate ageing-related …

Obesity is one of the worldwide prevalent disease caused by the imbalance between food
intake and energy expenditure. Over a 100 years of research demonstrate that …

Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis
are underlying causal components of diet-induced obesity in rodent models. This review …

Metabolic syndrome is a cluster of cardiovascular risk factors defined by the presence of
abdominal obesity, glucose intolerance, hypertension and/or dyslipidemia. It is a major …

Age‐related central neurodegenerative diseases, such as Alzheimer's and Parkinson's
disease, are a rising public health concern and have been plagued by repeated drug …

There is growing evidence that obesity is associated with brain inflammation in humans,
particularly in the hypothalamus where its presence may disrupt body weight control and …

Increased life expectancy in combination with modern life style and high prevalence of
obesity are important risk factors for development of neurodegenerative diseases …