Antibacterial prodrugs to overcome bacterial antimicrobial resistance
Antimicrobial resistance (AMR) is an increasingly concerning phenomenon that requires
urgent attention because it poses a threat to human and animal health. Bacteria undergo …
urgent attention because it poses a threat to human and animal health. Bacteria undergo …
[HTML][HTML] Phenazines: Natural products for microbial growth control
CA Sousa, M Ribeiro, F Vale, M Simões - HLife, 2024 - Elsevier
The unprecedented problem of antibiotic resistance has become a major challenge for
public health, which has contributed to an increase in infections caused by such bacteria …
public health, which has contributed to an increase in infections caused by such bacteria …
Identification of 6, 8-ditrifluoromethyl halogenated phenazine as a potent bacterial biofilm-eradicating agent
Bacterial biofilms are surface-attached communities consisting of non-replicating persister
cells encased within an extracellular matrix of biomolecules. Unlike bacteria that have …
cells encased within an extracellular matrix of biomolecules. Unlike bacteria that have …
Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens
S Wang, K Zhao, Z Chen, D Liu, S Tang, C Sun… - Antibiotics, 2024 - mdpi.com
It is crucial to discover novel antimicrobial drugs to combat resistance. This study
investigated the antibacterial properties of halicin (SU3327), an AI-identified anti-diabetic …
investigated the antibacterial properties of halicin (SU3327), an AI-identified anti-diabetic …
Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase
S Russo, HJ Rozeboom, HJ Wijma… - The FEBS …, 2024 - Wiley Online Library
Nitroreductases (NRs) are NAD (P) H‐dependent flavoenzymes that reduce nitro aromatic
compounds to their corresponding arylamines via the nitroso and hydroxylamine …
compounds to their corresponding arylamines via the nitroso and hydroxylamine …
Exploration and engineering of a nitroreductase for sustainable pharmaceutical synthesis
S Russo - 2024 - research.rug.nl
Abstract Nitroreductases (NRs) are NAD (P) H-dependent flavoenzymes that convert
nitroaromatic compounds into arylamines via the nitroso and hydroxylamine intermediates …
nitroaromatic compounds into arylamines via the nitroso and hydroxylamine intermediates …