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Applications of single-cell RNA sequencing in drug discovery and development
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
Precision treatment in advanced hepatocellular carcinoma
The past decade has witnessed significant advances in the systemic treatment of advanced
hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies …
hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies …
[HTML][HTML] What is a cell type and how to define it?
Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …
phenotypic properties at multiple levels, making them challenging to define, categorize, and …
Impact of the Human Cell Atlas on medicine
Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …
therapies. By identifying the specific cell types, states, programs and contexts where disease …
Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex
Elucidating the cellular organization of the cerebral cortex is critical for understanding brain
structure and function. Using large-scale single-nucleus RNA sequencing and spatial …
structure and function. Using large-scale single-nucleus RNA sequencing and spatial …
[HTML][HTML] Multimodal cell atlas of the ageing human skeletal muscle
Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and
are critical contributors to morbidity and mortality in older people. Deciphering the molecular …
are critical contributors to morbidity and mortality in older people. Deciphering the molecular …
Spatiotemporal omics for biology and medicine
The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …
understanding human life. Nonetheless, understanding the intricate mechanisms through …
Construction of a cross-species cell landscape at single-cell level
Individual cells are basic units of life. Despite extensive efforts to characterize the cellular
heterogeneity of different organisms, cross-species comparisons of landscape dynamics …
heterogeneity of different organisms, cross-species comparisons of landscape dynamics …
A spatiotemporal atlas of mouse liver homeostasis and regeneration
The mechanism by which mammalian liver cell responses are coordinated during tissue
homeostasis and perturbation is poorly understood, representing a major obstacle in our …
homeostasis and perturbation is poorly understood, representing a major obstacle in our …
Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk …
Background Cervical carcinoma (CC) represents a prevalent gynecological neoplasm, with
a discernible rise in prevalence among younger cohorts observed in recent years …
a discernible rise in prevalence among younger cohorts observed in recent years …