Exploring pancreatic beta-cell subgroups and their connectivity
Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …
The beta cell-immune cell interface in type 1 diabetes (T1D)
Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …
NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development
R Bohuslavova, V Fabriciova, O Smolik… - Nature …, 2023 - nature.com
NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β
cells. Disruption of Neurod1 during pancreatic development causes severe neonatal …
cells. Disruption of Neurod1 during pancreatic development causes severe neonatal …
Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6
Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …
[HTML][HTML] FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
Pancreatic β cells display functional and transcriptional heterogeneity in health and disease.
The sequence of events leading to β cell heterogeneity during metabolic stress is poorly …
The sequence of events leading to β cell heterogeneity during metabolic stress is poorly …
Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
Recent studies reported that pancreatic β-cells are heterogeneous in terms of their
transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic …
transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic …
Heterogeneous enhancer states orchestrate β cell responses to metabolic stress
Obesity-induced β cell dysfunction contributes to the onset of type 2 diabetes. Nevertheless,
elucidating epigenetic mechanisms underlying islet dysfunction at single cell level remains …
elucidating epigenetic mechanisms underlying islet dysfunction at single cell level remains …
Pancreatic β-cell failure, clinical implications, and therapeutic strategies in type 2 diabetes
D Cui, X Feng, S Lei, H Zhang, W Hu, S Yang… - Chinese Medical …, 2024 - mednexus.org
Pancreatic β-cell failure due to a reduction in function and mass has been defined as a
primary contributor to the progression of type 2 diabetes (T2D). Reserving insulin-producing …
primary contributor to the progression of type 2 diabetes (T2D). Reserving insulin-producing …
ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models
R Hu, X Chen, Q Su, Z Wang, X Wang… - Cell Death & …, 2024 - nature.com
Pancreatic β-cell failure by WFS1 deficiency is manifested in individuals with wolfram
syndrome (WS). The lack of a suitable human model in WS has impeded progress in the …
syndrome (WS). The lack of a suitable human model in WS has impeded progress in the …
Allo Beta Cell transplantation: specific features, unanswered questions, and immunological challenge
Type 1 diabetes (T1D) presents a persistent medical challenge, demanding innovative
strategies for sustained glycemic control and enhanced patient well-being. Beta cells are …
strategies for sustained glycemic control and enhanced patient well-being. Beta cells are …