piRNAs and PIWI proteins as diagnostic and prognostic markers of genitourinary cancers
K Hanusek, S Poletajew, P Kryst… - Biomolecules, 2022 - mdpi.com
piRNAs (PIWI-interacting RNAs) are small non-coding RNAs capable of regulation of
transposon and gene expression. piRNAs utilise multiple mechanisms to affect gene …
transposon and gene expression. piRNAs utilise multiple mechanisms to affect gene …
[HTML][HTML] The meaning of PIWI proteins in cancer development
M Litwin, A Szczepańska‑Buda… - Oncology …, 2017 - spandidos-publications.com
Cancer is a histologically and genetically heterogeneous population of tumor cells that
exhibits distinct molecular profiles determined by epigenetic alterations. P‑element‑induced …
exhibits distinct molecular profiles determined by epigenetic alterations. P‑element‑induced …
Human-specific subcellular compartmentalization of P-element induced wimpy testis-like (PIWIL) granules during germ cell development and spermatogenesis
M Gomes Fernandes, N He, F Wang… - Human …, 2018 - academic.oup.com
STUDY QUESTION What is the dynamics of expression of P-element induced wimpy testis-
like (PIWIL) proteins in the germline during human fetal development and spermatogenesis …
like (PIWIL) proteins in the germline during human fetal development and spermatogenesis …
Emerging roles for PIWI proteins in cancer
Y Tan, L Liu, M Liao, C Zhang, S Hu… - Acta biochimica et …, 2015 - academic.oup.com
It is generally accepted that PIWI proteins are predominately expressed in the germline but
absent in somatic tissues. Their best-characterized role is to suppress transposon …
absent in somatic tissues. Their best-characterized role is to suppress transposon …
[HTML][HTML] Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis
D Feng, K Yan, Y Zhou, H Liang, J Liang, W Zhao… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The human papillomavirus (HPV) oncoproteins E6 and E7 are risk factors that are primarily
responsible for the initiation and progression of cervical cancer, and they play a key role in …
responsible for the initiation and progression of cervical cancer, and they play a key role in …
Piwil 2 expression is correlated with disease-specific and progression-free survival of chemotherapy-treated bladder cancer patients
H Taubert, S Wach, R Jung, M Pugia, B Keck, S Bertz… - Molecular …, 2015 - Springer
Abstract Piwi-like 2 (Piwil 2) belongs to the family of Argonaute genes/proteins. The
expression of Piwil 2 is associated with stem cells. A role in tumorigenesis and/or tumor …
expression of Piwil 2 is associated with stem cells. A role in tumorigenesis and/or tumor …
Non-coding RNAs and splicing activity in testicular germ cell tumors
Testicular germ cell tumors (TGCTs) are the most common tumors in adolescent and young
men. Recently, genome-wide studies have made it possible to progress in understanding …
men. Recently, genome-wide studies have made it possible to progress in understanding …
Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ
IV Gainetdinov, YV Skvortsova, SA Kondratieva… - BMC cancer, 2018 - Springer
Background Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many
types of tumors. Interestingly, these proteins are downregulated in testicular germ cell …
types of tumors. Interestingly, these proteins are downregulated in testicular germ cell …
[HTML][HTML] Selective degradation of PL2L60 by metabolic stresses‑induced autophagy suppresses multi‑cancer growth
L Sun, F Hui, GY Tang, HL Shen… - Oncology …, 2024 - spandidos-publications.com
It has been reported that PL2L60 proteins, a product of PIWIL2 gene which might be
activated by an intragenic promoter, could mediate a common pathway specifically for …
activated by an intragenic promoter, could mediate a common pathway specifically for …
Identification of PIWIL1 Isoforms and Their Expression in Bovine Testes, Oocytes, and Early Embryos
SJ Russell, L Stalker, G Gilchrist, A Backx… - Biology of …, 2016 - academic.oup.com
PIWI proteins are members of the larger Argonaute family and bind to specific 24–32
nucleotide RNAs called PIWI-interacting RNAs (piRNAs). PIWI-interacting RNAs direct PIWI …
nucleotide RNAs called PIWI-interacting RNAs (piRNAs). PIWI-interacting RNAs direct PIWI …