Approaches to achieve high‐level heterologous protein production in plants
SJ Streatfield - Plant biotechnology journal, 2007 - Wiley Online Library
Plants offer an alternative to microbial fermentation and animal cell cultures for the
production of recombinant proteins. For protein pharmaceuticals, plant systems are …
production of recombinant proteins. For protein pharmaceuticals, plant systems are …
Plant-based vaccines
SJ Streatfield, JA Howard - International journal for parasitology, 2003 - Elsevier
Plant systems are reviewed with regard to their ability to express and produce subunit
vaccines. Examples of different types of expression systems producing a variety of vaccine …
vaccines. Examples of different types of expression systems producing a variety of vaccine …
Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn
CO Tacket, MF Pasetti, R Edelman, JA Howard… - Vaccine, 2004 - Elsevier
Previous clinical studies have demonstrated the feasibility of using edible transgenic plants
to deliver protective antigens as new oral vaccines. Transgenic corn is particularly attractive …
to deliver protective antigens as new oral vaccines. Transgenic corn is particularly attractive …
A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine
BJ Lamphear, JM Jilka, L Kesl, M Welter, JA Howard… - Vaccine, 2004 - Elsevier
Recombinant plant expression systems offer a means to produce large quantities of selected
antigens for subunit vaccines. Cereals are particularly well-suited expression vehicles since …
antigens for subunit vaccines. Cereals are particularly well-suited expression vehicles since …
Delivery of subunit vaccines in maize seed
BJ Lamphear, SJ Streatfield, JM Jilka… - Journal of Controlled …, 2002 - Elsevier
The use of recombinant gene technologies by the vaccine industry has revolutionized the
way antigens are generated, and has provided safer, more effective means of protecting …
way antigens are generated, and has provided safer, more effective means of protecting …
Mucosal immunization using recombinant plant-based oral vaccines
SJ Streatfield - Methods, 2006 - Elsevier
The induction of mucosal immunity is very important in conferring protection against
pathogens that typically invade via mucosal surfaces. Delivery of a vaccine to a mucosal …
pathogens that typically invade via mucosal surfaces. Delivery of a vaccine to a mucosal …
Subcellular targeting is a key condition for high‐level accumulation of cellulase protein in transgenic maize seed
EE Hood, R Love, J Lane, J Bray… - Plant biotechnology …, 2007 - Wiley Online Library
Ethanol from lignocellulosic biomass is being pursued as an alternative to petroleum‐based
transportation fuels. To succeed in this endeavour, efficient digestion of cellulose into …
transportation fuels. To succeed in this endeavour, efficient digestion of cellulose into …
Corn as a production system for human and animal vaccines
SJ Streatfield, JR Lane, CA Brooks, DK Barker… - Vaccine, 2003 - Elsevier
The synthesis of selected antigens in plants and their oral delivery has great potential for
reducing the costs of vaccine production and administration. The application of this …
reducing the costs of vaccine production and administration. The application of this …
Plant platforms for efficient heterologous protein production
Production of recombinant proteins is primarily established in cultures of mammalian, insect
and bacterial cells. Concurrently, concept of using plants to produce high-value …
and bacterial cells. Concurrently, concept of using plants to produce high-value …
Expression of the Newcastle disease virus fusion protein in transgenic maize and immunological studies
O Guerrero-Andrade, E Loza-Rubio… - Transgenic …, 2006 - Springer
Transgenic plants have been employed successfully as a low-cost system for the production
of therapeutically valuable proteins, including antibodies, antigens and hormones. Here, we …
of therapeutically valuable proteins, including antibodies, antigens and hormones. Here, we …