A review on lymphocyte radiosensitivity and its impact on radiotherapy

H Paganetti - Frontiers in Oncology, 2023 - frontiersin.org
It is well known that radiation therapy causes lymphopenia in patients and that this is
correlated with a negative outcome. The mechanism is not well understood because …

Radioprotection and radiomitigation: from the bench to clinical practice

E Obrador, R Salvador, JI Villaescusa, JM Soriano… - Biomedicines, 2020 - mdpi.com
The development of protective agents against harmful radiations has been a subject of
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …

RENEB Inter-laboratory comparison 2021: Inter-assay comparison of eight dosimetry assays

M Port, JF Barquinero, D Endesfelder… - Radiation …, 2023 - meridian.allenpress.com
Tools for radiation exposure reconstruction are required to support the medical management
of radiation victims in radiological or nuclear incidents. Different biological and physical …

Radiation-induced immunity and toxicities: the versatility of the cGAS-STING pathway

J Constanzo, J Faget, C Ursino, C Badie… - Frontiers in …, 2021 - frontiersin.org
In the past decade, radiation therapy (RT) entered the era of personalized medicine,
following the striking improvements in radiation delivery and treatment planning …

Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: A systematic review

J Lacombe, C Sima, SA Amundson, F Zenhausern - PloS one, 2018 - journals.plos.org
Purpose To compile a list of genes that have been reported to be affected by external
ionizing radiation (IR) and to assess their performance as candidate biomarkers for …

Inter-laboratory comparison of gene expression biodosimetry for protracted radiation exposures as part of the RENEB and EURADOS WG10 2019 exercise

M Abend, SA Amundson, C Badie, K Brzoska… - Scientific reports, 2021 - nature.com
Large-scale radiation emergency scenarios involving protracted low dose rate radiation
exposure (eg a hidden radioactive source in a train) necessitate the development of high …

Overcoming challenges in human saliva gene expression measurements

P Ostheim, A Tichý, I Sirak, M Davidkova, MM Stastna… - Scientific reports, 2020 - nature.com
Saliva, as a non-invasive and easily accessible biofluid, has been shown to contain RNA
biomarkers for prediction and diagnosis of several diseases. However, systematic analysis …

Transcriptomics for radiation biodosimetry: progress and challenges

SA Amundson - International journal of radiation biology, 2023 - Taylor & Francis
Purpose Transcriptomic-based approaches are being developed to meet the needs for large-
scale radiation dose and injury assessment and provide population triage following a …

Generation of a transcriptional radiation exposure signature in human blood using long-read nanopore sequencing

L Cruz-Garcia, G O'Brien, B Sipos… - Radiation …, 2020 - meridian.allenpress.com
In the event of a large-scale event leading to acute ionizing radiation exposure, high-
throughput methods would be required to assess individual dose estimates for triage …

In vivo validation of alternative FDXR transcripts in human blood in response to ionizing radiation

L Cruz-Garcia, G O'brien, B Sipos, S Mayes… - International Journal of …, 2020 - mdpi.com
Following cell stress such as ionising radiation (IR) exposure, multiple cellular pathways are
activated. We recently demonstrated that ferredoxin reductase (FDXR) has a remarkable IR …