A unique understanding of traditional medicine of pomegranate, Punica granatum L. and its current research status

S Ge, L Duo, J Wang, J Yang, Z Li, Y Tu - Journal of ethnopharmacology, 2021 - Elsevier
Abstract Ethnopharmacological relevance Pomegranate, Punica granatum L., has been
used in traditional medicine in China and several regions of the world including Ayurveda …

Possible use of Punica granatum (Pomegranate) in cancer therapy

AD Khwairakpam, D Bordoloi, KK Thakur… - Pharmacological …, 2018 - Elsevier
The intake of fruits has proven to reduce the risk and incidence of cancer worldwide and
plays a crucial role in cancer prevention. Pomegranate (Punica granatum), which belongs to …

Pomegranate bioactive constituents target multiple oncogenic and oncosuppressive signaling for cancer prevention and intervention

TL Wong, KR Strandberg, CR Croley, SE Fraser… - Seminars in cancer …, 2021 - Elsevier
Cancer remains to be the second highest cause of mortality in our society, falling just short of
heart disease. Despite major advancement in cancer therapy over the past decade …

[HTML][HTML] Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling

S Saber, EE Abd El-Fattah, AM Abdelhamid… - Biomedicine & …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …

Benzo [a] pyrene immunogenetics and immune archetype reprogramming of lung

EE Abd El-Fattah, AM Abdelhamid - Toxicology, 2021 - Elsevier
Overexposure to carcinogenic precursor, benzo [a] pyrene [BaP], modulates the lung
immune microenvironment. The present review seeks to elucidate novel pathways behind …

AKT-AMPKα-mTOR-dependent HIF-1α activation is a new therapeutic target for cancer treatment: a novel approach to repositioning the antidiabetic drug sitagliptin for …

EE Abd El-Fattah, S Saber, ME Youssef… - Frontiers in …, 2022 - frontiersin.org
HIF-1α is a key factor promoting the development of hepatocellular carcinoma (HCC). As
well, AKT-AMPKα-mTOR signaling is a promising target for cancer therapy. Yet, the AKT …

[HTML][HTML] Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application

AM Abdelhamid, S Saber, ME Youssef… - Biomedicine & …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is on the rise worldwide, and its incidence in diabetic
patients is two to three times that of non-diabetics. Current therapeutic options fail to provide …

Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds: comparison with conventional drugs acting on the same molecular …

MM Rahman, MR Islam, S Akash, ME Hossain… - Heliyon, 2023 - cell.com
Pomegranate, scientifically known as Punica granatum, has been a traditional medicinal
remedy since ancient times. Research findings have shown that using pomegranate extracts …

Metformin modulate immune fitness in hepatocellular carcinoma: molecular and cellular approach

EE Abd El-Fattah, AY Zakaria - International Immunopharmacology, 2022 - Elsevier
Hyperinsulinemia, hyperglycemia, and chronic inflammation may play a role in
hepatocellular carcinoma (HCC). Treatment of HCC patients with the antidiabetic medication …

Pomegranate peel extract sensitizes hepatocellular carcinoma cells to ionizing radiation, induces apoptosis and inhibits MAPK, JAK/STAT3, β-catenin/NOTCH, and …

MMM Elbakry, NM ElBakary… - Integrative Cancer …, 2023 - journals.sagepub.com
Tumor resistance is typically blamed for the failure of radiotherapy and chemotherapy to
treat cancer in clinic patients. To improve the cytotoxicity of tumor cells using radiation in …