The PIWI-interacting RNA (piRNA) pathway is a conserved defense system that protects the
genome integrity of the animal germline from deleterious transposable elements. Targets of …

PIWI-interacting RNAs (piRNAs) are germline-enriched small RNAs that control transposons
to maintain genome integrity. To achieve this, upon being processed from piRNA precursors …

RNA interference systems depend on the synthesis of small RNA precursors whose
sequences define the target spectrum of these silencing pathways. The Drosophila …

Small non-coding RNAs called piRNAs serve as guides for an adaptable immune system
that represses transposable elements in germ cells of Metazoa. In Drosophila the RDC …

The eukaryotic genome is packaged into transcriptionally active euchromatin and silent
heterochromatin, with most studies focused on the former encompassing the majority of …

The conserved THO/TREX (transcription/export) complex is critical for pre-mRNA processing
and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA transcribed by RNA …

Reproductive isolation defines species divergence and is linked to adaptive evolution of
hybrid incompatibility genes. Hybrids between Drosophila melanogaster and Drosophila …

Eukaryotic genomes are organized hierarchically into chromatin structures by histones.
Despite extensive research for over 30 years, not only the fundamental structure of the 30 …

PIWI-interacting RNAs (piRNAs) guide transposable element repression in animal germ
lines. In Drosophila, piRNAs are produced from heterochromatic loci, called piRNA clusters …

Summary In Drosophila, 23–30 nt long PIWI-interacting RNAs (piRNAs) direct the protein
Piwi to silence germline transposon transcription. Most germline piRNAs derive from dual …