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[HTML][HTML] Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development
AP Caccavano, A Vlachos, N McLean, S Kimmel… - …, 2024 - pmc.ncbi.nlm.nih.gov
Opioid receptors within the CNS regulate pain sensation and mood and are key targets for
drugs of abuse. Within the adult rodent hippocampus (HPC), μ-opioid receptor agonists …
drugs of abuse. Within the adult rodent hippocampus (HPC), μ-opioid receptor agonists …
Modeling Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability
Neurodevelopmental disorders often impair multiple cognitive domains. For instance, a
genetic epilepsy syndrome might cause seizures due to cortical hyperexcitability and …
genetic epilepsy syndrome might cause seizures due to cortical hyperexcitability and …
Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturation
M Bershteyn, H Zhou, L Fuentealba, C Chen… - bioRxiv, 2024 - biorxiv.org
Medial ganglionic eminence-derived inhibitory GABAergic pallial interneurons (MGE-pINs)
are essential regulators of cortical circuits; their dysfunction is associated with numerous …
are essential regulators of cortical circuits; their dysfunction is associated with numerous …
Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the …
FP Szabó, V Sigutova, AM Schneider… - Journal of … - Wiley Online Library
Neural networks are established throughout cortical development, which require the right
ratios of glutamatergic and GABAergic neurons. Developmental disturbances in pyramidal …
ratios of glutamatergic and GABAergic neurons. Developmental disturbances in pyramidal …