Ubiquitin-like protein conjugation: structures, chemistry, and mechanism
Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …
SUMO conjugation–a mechanistic view
A Pichler, C Fatouros, H Lee, N Eisenhardt - Biomolecular concepts, 2017 - degruyter.com
The regulation of protein fate by modification with the small ubiquitin-related modifier
(SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly …
(SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly …
Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase
E3 protein ligases enhance transfer of ubiquitin-like (Ubl) proteins from E2 conjugating
enzymes to substrates by stabilizing the thioester-charged E2~ Ubl in a closed configuration …
enzymes to substrates by stabilizing the thioester-charged E2~ Ubl in a closed configuration …
Capturing a substrate in an activated RING E3/E2–SUMO complex
FC Streich Jr, CD Lima - Nature, 2016 - nature.com
Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins
such as small ubiquitin-like modifier (SUMO) regulates processes including protein …
such as small ubiquitin-like modifier (SUMO) regulates processes including protein …
A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly
N Eisenhardt, VK Chaugule, S Koidl… - Nature structural & …, 2015 - nature.com
SUMO chains act as stress-induced degradation tags or repair factor–recruiting signals at
DNA lesions. Although E1 activating, E2 conjugating and E3 ligating enzymes efficiently …
DNA lesions. Although E1 activating, E2 conjugating and E3 ligating enzymes efficiently …
Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1
M Lussier-Price, HM Wahba, XH Mascle… - Nucleic acids …, 2022 - academic.oup.com
SUMO proteins are important regulators of many key cellular functions in part through their
ability to form interactions with other proteins containing SUMO interacting motifs (SIMs) …
ability to form interactions with other proteins containing SUMO interacting motifs (SIMs) …
Arabidopsis TCP transcription factors interact with the SUMO conjugating machinery in nuclear foci
MJ Mazur, BJ Spears, A Djajasaputra… - Frontiers in Plant …, 2017 - frontiersin.org
In Arabidopsis more than 400 proteins have been identified as SUMO targets, both in vivo
and in vitro. Among others, transcription factors (TFs) are common targets for SUMO …
and in vitro. Among others, transcription factors (TFs) are common targets for SUMO …
The WNT signaling pathway contributes to dectin-1-dependent inhibition of Toll-like receptor-induced inflammatory signature
Macrophages regulate cell fate decisions during microbial challenges by carefully titrating
signaling events activated by innate receptors such as dectin-1 or Toll-like receptors (TLRs) …
signaling events activated by innate receptors such as dectin-1 or Toll-like receptors (TLRs) …
Coding and noncoding expression patterns associated with rare obesity-related disorders: Prader–Willi and Alström syndromes
MG Butler, K Wang, JD Marshall… - … in genomics and …, 2015 - Taylor & Francis
Obesity is accompanied by hyperphagia in several classical genetic obesity-related
syndromes that are rare, including Prader–Willi syndrome (PWS) and Alström syndrome …
syndromes that are rare, including Prader–Willi syndrome (PWS) and Alström syndrome …
Characterization of a C-terminal SUMO-interacting motif present in select PIAS-family proteins
The human PIAS proteins are small ubiquitin-like modifier (SUMO) E3 ligases that
participate in important cellular functions. Several of these functions depend on a conserved …
participate in important cellular functions. Several of these functions depend on a conserved …