Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …

Carbohydrates (glycans, saccharides, sugars) are everywhere. In fact, glycan–protein
interactions are involved in many essential processes of life and disease. The …

HIV-1 Env, a trimer of gp120-gp41 heterodimers, mediates membrane fusion after binding
host receptor CD4. Receptor binding displaces V1V2 loops from Env's apex, allowing …

Recent advances in single-particle cryo-electron microscopy (cryoEM) have resulted in
determination of an increasing number of protein structures with resolved glycans. However …

Broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals inform HIV-
1 vaccine design efforts. Develo** bNAbs with increased efficacy requires understanding …

Glycoproteins play a central role in many biological processes including disease
mechanisms. Nevertheless, because glycoproteins are heterogeneous entities, it remains …

The development of an HIV vaccine has been hampered by the extraordinary mutability and
genetic diversity of the virus, particularly the substantial sequence diversity of gp120 and gp …

Owing to the difficulties associated with working with carbohydrates, validating glycan 3D
structures prior to deposition into the Protein Data Bank has become a staple of the structure …

Broadly neutralizing antibodies (bNAbs) for HIV-1 prevention or cure strategies must inhibit
transmitted/founder and reservoir viruses. Establishing sensitivity of circulating viruses to …

The heterogeneity, mobility and complexity of glycans in glycoproteins have been, and
currently remain, significant challenges in structural biology. These aspects present unique …