Suppression of allograft rejection is central to successful organ transplantation; thus,
immunosuppressive agents are crucial for successful allograft function. Immunosuppressive …

The identification and characterization of regulatory T (TReg) cells that can control immune
responsiveness to alloantigens have opened up exciting opportunities for new therapies in …

The first human orthotopic liver transplantation (LT) in Europe was performed by Sir Roy
Calne in Cambridge in 1968 [1], only one year after the first successful human liver …

Effective immunosuppression is an essential pre-requisite for successful organ
transplantation and improvements in outcome after transplantation have to a large extent …

T-cell depletion facilitates reduced immunosuppression following organ transplantation and
has been suggested to be pro-tolerant. However, the characteristics of post-depletional T …

Background Insight into the mechanisms of organ engraftment and acquired tolerance has
made it possible to facilitate these mechanisms, by tailoring the timing and dosage of …

RESULTS FROM A HUMAN RENAL ALLOGRAFT TOLERANCE TRIAL EVALUAT... :
Transplantation RESULTS FROM A HUMAN RENAL ALLOGRAFT TOLERANCE TRIAL …

Transplantation of organs between genetically different individuals of the same species
causes a T cell–mediated immune response that, if left unchecked, results in rejection and …

Campath‐1H, an anti‐CD52 monoclonal antibody, was used as induction therapy (40 mg iv
total dose) in 29 primary human renal transplants, and the patients were maintained on …

Remarkable progress has been made in islet transplantation over a span of 40 years. Once
just an experimental curiosity in mice, this therapy has moved forward, and can now provide …