Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

For the past 30 years, improvements in the survival of patients with osteosarcoma have been
mostly incremental. Despite evidence of genomic instability and a high frequency of …

Simple Summary Osteosarcoma is the most common malignant bone tumor in children, with
a 5-year survival rate ranging from 70% to 20% depending on the aggressiveness of the …

Purpose To compare three-drug chemotherapy with cisplatin, doxorubicin, and methotrexate
with four-drug chemotherapy with cisplatin, doxorubicin, methotrexate, and ifosfamide for the …

Purpose To determine whether the addition of ifosfamide and/or muramyl tripeptide (MTP)
encapsulated in liposomes to cisplatin, doxorubicin, and high-dose methotrexate (HDMTX) …

Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
etiologic and biologic factors in osteosarcoma. Select the appropriate diagnostic work-up for …

The use of animals as models to address fundamental questions on the molecular basis of
cancer and for preclinical study of cancer therapeutics has a long history, and important …

Osteosarcoma (OSA) is the most common form of malignant bone cancer in children and
dogs, although the disease occurs in dogs approximately 10 times more frequently than in …

Spontaneous tumors in dogs and cats are appropriate and valid model tumor systems
available for testing cancer therapeutic agents or studying cancer biology. The pet …

Osteosarcoma is the most common primary tumor of bone. Approximately 2/3 of patients
who present with localized osteosarcoma can be expected to be cured of their disease with …