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Epigenetic mechanisms in neurogenesis
In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …
embryonic development, cells are directed toward their future lineages, and DNA …
Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
DNA methylation has critical roles in the nervous system and has been traditionally
considered to be restricted to CpG dinucleotides in metazoan genomes. Here we show that …
considered to be restricted to CpG dinucleotides in metazoan genomes. Here we show that …
[HTML][HTML] DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
The establishment of DNA methylation patterns requires de novo methylation that occurs
predominantly during early development and gametogenesis in mice. Here we demonstrate …
predominantly during early development and gametogenesis in mice. Here we demonstrate …
Structure and function of mammalian DNA methyltransferases
DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …
regulation, chromatin structure, development and disease. Here, we review the structures …
Eukaryotic cytosine methyltransferases
▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence
promoters, especially those associated with transposons and imprinted genes. Cytosine …
promoters, especially those associated with transposons and imprinted genes. Cytosine …
The DNA methyltransferases of mammals
The biological significance of 5-methylcytosine was in doubt for many years, but is no
longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by …
longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by …
Regulation and function of DNA methylation in plants and animals
DNA methylation is an important epigenetic mark involved in diverse biological processes.
In plants, DNA methylation can be established through the RNA-directed DNA methylation …
In plants, DNA methylation can be established through the RNA-directed DNA methylation …
Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
Activation of the promoters of parasitic sequence elements (transposons and endogenous
retroviruses) causes dysregulation of nearby cellular genes and induces new mutations via …
retroviruses) causes dysregulation of nearby cellular genes and induces new mutations via …
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
Abstract Background: Histone H3 lysine 9 (H3-K9) methylation and DNA methylation are
characteristic hallmarks of mammalian heterochromatin. H3-K9 methylation was recently …
characteristic hallmarks of mammalian heterochromatin. H3-K9 methylation was recently …