Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …

Metabolism is the fundamental process for all cellular functions. For decades, there has
been growing evidence with regard to the relationship between metabolism and malignant …

Gluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated
gluconeogenesis during type 2 diabetes (T2D) contributes to chronic hyperglycemia …

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that
promotes fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS). We and …

The metabolic adaptations that support oncogenic growth can also render cancer cells
dependent on certain nutrients. Along with the Warburg effect, increased utilization of …

Liver disease is linked to a decreased capacity of hepatocytes to divide. In addition, cellular
metabolism is important for tissue homeostasis and regeneration. Since metabolic changes …

Genomics has contributed to the treatment of a fraction of cancer patients. However, there is
a need to profile the proteins that define the phenotype of cancer and its pathogenesis. The …

Background Deregulation of the tricarboxylic acid cycle (TCA) due to mutations in specific
enzymes or defective aerobic metabolism is associated with tumour growth. Aconitase 2 …

Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc
transferase (OGT) can sense the availability of metabolites and also modify target proteins …