Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …

In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …

An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic
cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and …

In recent years, spatial transcriptomics (ST) technologies have developed rapidly and have
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …

Aberrant alternative pre-mRNA splicing plays a critical role in MYC-driven cancers and
therefore may represent a therapeutic vulnerability. Here, we show that neuroblastoma, a …

The immune response is tailored to the environment in which it takes place. Immune cells
sense and adapt to changes in their surroundings, and it is now appreciated that in addition …

The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like sha** intricate tissue functions and …

As modern biological sciences evolve from investigation of individual molecules and
pathways to growing emphasis on global and systems-based processes, increasing efforts …

The tumor microenvironment (TME) constitutes a complex microenvironment comprising a
diverse array of immune cells and stromal components. Within this intricate context, tumor …

Tumor-associated macrophages (TAMs) constitute an important part of the tumor
microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia …