DNA end resection: mechanism and control
P Cejka, LS Symington - Annual review of genetics, 2021 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
Metalloimmunology: The metal ion-controlled immunity
Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …
all enzymes and are critically involved in virtually all fundamental biological processes …
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells
DNA end resection has a key role in double-strand break repair and DNA replication.
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …
Manganese is essential for neuronal health
KJ Horning, SW Caito, KG Tipps… - Annual review of …, 2015 - annualreviews.org
The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …
[HTML][HTML] DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities
Summary MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-
strand break repair (DSBR), detection, and signaling; yet, how its endo-and exonuclease …
strand break repair (DSBR), detection, and signaling; yet, how its endo-and exonuclease …
Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks
To repair double-strand DNA breaks by homologous recombination, the 5′-terminated
DNA strand must first be resected, which generates 3′ single-stranded DNA overhangs …
DNA strand must first be resected, which generates 3′ single-stranded DNA overhangs …
[HTML][HTML] Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions
M Rotheneder, K Stakyte, E van de Logt, JD Bartho… - Molecular cell, 2023 - cell.com
The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers.
Characterization of genetic alterations will improve our understanding and therapies for this …
Characterization of genetic alterations will improve our understanding and therapies for this …