The assembly and disassembly of microtubules can generate pushing and pulling forces
that, together with motor proteins, contribute to the correct positioning of chromosomes …

Mechanical work in cells is performed by specialized motor proteins that operate in a
continuous mechanochemical cycle. Less complex, but still efficient,'one-shot'motors …

Microtubules are long filamentous protein structures that randomly alternate between
periods of elongation and shortening in a process termed dynamic instability. The average …

We develop a mathematical model that describes key details of actin dynamics in protrusion
associated with cell motility. The model is based on the dendritic-nucleation hypothesis for …

Motile cells explore their surrounding milieu by extending thin dynamic protrusions, or
filopodia. The growth of filopodia is driven by actin filament bundles that polymerize …

Sperm of the nematode, Ascaris suum, crawl using lamellipodial protrusion, adhesion and
retraction, a process analogous to the amoeboid motility of other eukaryotic cells. However …

Bipolar spindle assembly requires a balance of forces where kinesin-5 produces outward
pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein …

During mitosis, chromosomes become attached to microtubules that emanate from the two
spindle poles. Thereafter, a chromosome moves along these microtubule" tracks" as it …

We present a novel platform for the large-scale simulation of three-dimensional fibrous
structures immersed in a Stokesian fluid and evolving under confinement or in free-space in …

Individual dynamic microtubules can generate pushing or pulling forces when their growing
or shrinking ends are in contact with cellular objects such as the cortex or chromosomes …