Valproic acid (VPA) is a very effective anticonvulsant and mood stabilizer with relatively few
side effects. Being an epigenetic modulator, it undergoes clinical trials for the treatment of …

PURPOSE OF REVIEW Seizure disorders are the most frequent major neurologic
complication in pregnancy, affecting 0.3% to 0.8% of all gestations. Women of childbearing …

Importance Women with epilepsy frequently need antiseizure medication (ASM) to prevent
seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure to …

Drug resistant epilepsy (DRE) is defined as the persistence of seizures despite at least two
syndrome-adapted antiseizure drugs (ASD) used at efficacious daily dose. Despite the …

Importance Women with epilepsy are recommended high doses of folic acid before and
during pregnancy owing to risk of congenital anomalies associated with antiseizure …

Women with epilepsy (WWE) wishing for a child represent a highly relevant subgroup of
epilepsy patients. The treating epileptologist needs to delineate the epilepsy syndrome and …

Abstract EDITOR'S NOTE The article “Update on Antiseizure Medications 2022” by Dr Abou-
Khalil was first published in the February 2016 Epilepsy issue of Continuum: Lifelong …

Background The neurodevelopmental effects of fetal exposure to most antiseizure
medications are unclear. We aimed to investigate the effects of fetal exposure to commonly …

Background Among women with epilepsy, studies regarding changes in seizure frequency
during pregnancy have been limited by the lack of an appropriate nonpregnant comparator …

Importance The neurodevelopmental risks of fetal exposure are uncertain for many
antiseizure medications (ASMs). Objective To compare children at 2 years of age who were …