The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes
and neurological disorders, among many, has been reported. Cinnamic acid is obtained …

Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

Ethnopharmacological relevance The traditional use of Prunus species against skin
diseases and especially for skin lightning cosmeceutical purposes is widespread in many …

Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its
inhibitors could be useful in preventing melanin-related diseases. To find potential …

A novel series of twenty-seven cinnamides constituted by cinnamic acid derivatives liked to
1-aryl piperazines were synthesized and evaluated for their potential inhibitory diphenolase …

To find new potential tyrosinase inhibitors, a diverse range of 2-arylchromone-4-thione
derivatives (2a–2p) were designed and synthesized by employing a multistep strategy, and …

Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …

Tyrosinase and its related proteins are responsible for pigmentation disorders, and inhibiting
tyrosinase is an established strategy to treat hyperpigmentation. The carbonyl scaffolds can …

Benzothiazepines are pharmacologically active compounds, frequently utilized as a
precursor for acquiring versatile molecules with several bioactivities including anti …

Asparagus contains high quantity of polyphenols, including gallic acid, coumaric acid,
chlorogenic acid, quercetin, p-hydroxybenzoic acid, rutin, trans-4-hydroxycinnamic acid, and …