Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …
Activation of PPARα enhances astroglial uptake and degradation of β-amyloid
Astrocytes are a type of glial cell that are activated in the brain tissue of patients with
Alzheimer's disease to induce the accumulation of amyloid (Aβ). We previously found that a …
Alzheimer's disease to induce the accumulation of amyloid (Aβ). We previously found that a …
[HTML][HTML] Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model
The response of the lysosomes, the waste clearance machinery of the cell, to different
environmental stimuli is coordinated by a gene network with a master regulator Transcription …
environmental stimuli is coordinated by a gene network with a master regulator Transcription …
Visible light-driven conjunctive olefination
D Filippini, M Silvi - Nature Chemistry, 2022 - nature.com
Carboxylic acids and aldehydes are ubiquitous in chemistry and are native functionalities in
many bioactive molecules and natural products. As such, a general cross-coupling process …
many bioactive molecules and natural products. As such, a general cross-coupling process …
Treadmill exercise reduces α-synuclein spreading via PPARα
This study underlines the importance of treadmill exercise in reducing α-synuclein (α-syn)
spreading in the A53T brain and protecting nigral dopaminergic neurons. Preformed α-syn …
spreading in the A53T brain and protecting nigral dopaminergic neurons. Preformed α-syn …
Activation of PPARα exhibits therapeutic efficacy in a mouse model of juvenile neuronal ceroid lipofuscinosis
Juvenile neuronal ceroid lipofuscinosis (JNCL) is a fatal inherited neurodegenerative
disease of children that occurs because of defective function of the lysosomal membrane …
disease of children that occurs because of defective function of the lysosomal membrane …
[HTML][HTML] Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α
Peroxisome proliferator-activated receptor α (PPARα) is a transcription factor that regulates
genes involved in fatty acid catabolism. Here, we provide evidence that PPARα is …
genes involved in fatty acid catabolism. Here, we provide evidence that PPARα is …
Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders
Lysosomes are ubiquitous membrane-enclosed organelles filled with an acidic interior and
are central to the autophagic, endocytic, or phagocytic pathway. In contrast to its classical …
are central to the autophagic, endocytic, or phagocytic pathway. In contrast to its classical …
Iterative One-Carbon Homologation of Unmodified Carboxylic Acids
E Wheatley, H Melnychenko, M Silvi - Journal of the American …, 2024 - ACS Publications
The one-carbon homologation of carboxylic acids is a valuable route to construct families of
homologues, which play fundamental roles in chemistry and biology. However, known …
homologues, which play fundamental roles in chemistry and biology. However, known …