A narrative review on plasminogen activator inhibitor-1 and its (patho) physiological role: to target or not to target?
M Sillen, PJ Declerck - International journal of molecular sciences, 2021 - mdpi.com
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen
activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system …
activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system …
[HTML][HTML] Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment
N Bourebaba, TH Ngo, A Śmieszek… - Biomedicine & …, 2022 - Elsevier
Sex hormone binding globulin (SHBG) is a hepatokine that binds to circulating steroid
hormones (testosterone, oestradiol) to regulate their concentration in the bloodstream …
hormones (testosterone, oestradiol) to regulate their concentration in the bloodstream …
Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity
EY Zhen, YQ Chen, AM Russell… - Proceedings of the …, 2023 - National Acad Sciences
Triglyceride (TG) metabolism is highly regulated by angiopoietin-like protein (ANGPTL)
family members [YQ Chen et al., J. Lipid Res. 61, 1203–1220 (2020)]. During feeding …
family members [YQ Chen et al., J. Lipid Res. 61, 1203–1220 (2020)]. During feeding …
The roles and associated mechanisms of adipokines in development of metabolic syndrome
JE Kim, JS Kim, MJ Jo, E Cho, SY Ahn, YJ Kwon, GJ Ko - Molecules, 2022 - mdpi.com
Metabolic syndrome is a cluster of metabolic indicators that increase the risk of diabetes and
cardiovascular diseases. Visceral obesity and factors derived from altered adipose tissue …
cardiovascular diseases. Visceral obesity and factors derived from altered adipose tissue …
Circulating PCSK9 as a prognostic biomarker of cardiovascular events in individuals with type 2 diabetes: evidence from a 16.8-year follow-up study
Background Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of
morbidity and mortality, being twofold to fourfold more common in patients with type 2 …
morbidity and mortality, being twofold to fourfold more common in patients with type 2 …
Impact of fenofibrate on NAFLD/NASH: A genetic perspective
Highlights•NAFLD is highly prevalent and affects at least one-third of the global
population.•Currently, there is no drug to cure NAFLD.•Fenofibrate is a PPARα agonist with …
population.•Currently, there is no drug to cure NAFLD.•Fenofibrate is a PPARα agonist with …
Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll‐like receptor 2 and plasminogen activator inhibitor‐1
Abstract Plasminogen activator inhibitor‐1 (PAI‐1) is associated with nonalcoholic fatty liver
disease (NAFLD) by lipid accumulation in the liver. In this study, we showed that …
disease (NAFLD) by lipid accumulation in the liver. In this study, we showed that …
Adipokines and bacterial metabolites: A pivotal molecular bridge linking obesity and gut microbiota dysbiosis to target
T Turpin, K Thouvenot, MP Gonthier - Biomolecules, 2023 - mdpi.com
Adipokines are essential mediators produced by adipose tissue and exert multiple biological
functions. In particular, adiponectin, leptin, resistin, IL-6, MCP-1 and PAI-1 play specific roles …
functions. In particular, adiponectin, leptin, resistin, IL-6, MCP-1 and PAI-1 play specific roles …
[HTML][HTML] Recent developments in adipose tissue-secreted factors and their target organs
J Navarro-Perez, A Vidal-Puig, S Carobbio - Current Opinion in Genetics & …, 2023 - Elsevier
The white adipose tissue's primary roles are to store and mobilise energy, which is very
different from the brown adipose tissue's function of using fuel to generate heat and maintain …
different from the brown adipose tissue's function of using fuel to generate heat and maintain …
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities
Metastatic uveal melanoma remains incurable at present. We previously demonstrated that
loss of BAP1 gene expression in tumour cells triggers molecular mechanisms of …
loss of BAP1 gene expression in tumour cells triggers molecular mechanisms of …