The evolving metabolic landscape of chromatin biology and epigenetics
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
Physiological signaling functions of reactive oxygen species in stem cells: from flies to man
SA Sinenko, TY Starkova, AA Kuzmin… - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …
[HTML][HTML] Metabolic maturation media improve physiological function of human iPSC-derived cardiomyocytes
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential
for the study of human cardiac disorders. However, their physiological immaturity severely …
for the study of human cardiac disorders. However, their physiological immaturity severely …
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
Y Shiba, T Gomibuchi, T Seto, Y Wada, H Ichimura… - Nature, 2016 - nature.com
Induced pluripotent stem cells (iPSCs) constitute a potential source of autologous patient-
specific cardiomyocytes for cardiac repair, providing a major benefit over other sources of …
specific cardiomyocytes for cardiac repair, providing a major benefit over other sources of …
Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair
Background: Advancing structural and functional maturation of stem cell–derived
cardiomyocytes remains a key challenge for applications in disease modeling, drug …
cardiomyocytes remains a key challenge for applications in disease modeling, drug …
Therapeutic approaches for cardiac regeneration and repair
Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …
Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
IY Shadrin, BW Allen, Y Qian, CP Jackman… - Nature …, 2017 - nature.com
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …
Chemically defined generation of human cardiomyocytes
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are
efficient but require complex, undefined medium constituents that hinder further elucidation …
efficient but require complex, undefined medium constituents that hinder further elucidation …
A brief review of current maturation methods for human induced pluripotent stem cells-derived cardiomyocytes
Cardiovascular diseases are the leading cause of death worldwide. Therefore, the discovery
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …