[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal

R Kandimalla, V Thirumala, PH Reddy - Biochimica et Biophysica Acta …, 2017 - Elsevier
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …

Fear memory

I Izquierdo, CRG Furini, JC Myskiw - Physiological reviews, 2016 - journals.physiology.org
Fear memory is the best-studied form of memory. It was thoroughly investigated in the past
60 years mostly using two classical conditioning procedures (contextual fear conditioning …

AMPARs and synaptic plasticity: the last 25 years

RL Huganir, RA Nicoll - Neuron, 2013 - cell.com
The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

Insulin action in brain regulates systemic metabolism and brain function

A Kleinridders, HA Ferris, W Cai, CR Kahn - Diabetes, 2014 - Am Diabetes Assoc
Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …

The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity

AH Dyer, C Vahdatpour, A Sanfeliu, D Tropea - Neuroscience, 2016 - Elsevier
Abstract Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …

The many faces of insulin-like peptide signalling in the brain

AM Fernandez, I Torres-Alemán - Nature Reviews Neuroscience, 2012 - nature.com
Central and peripheral insulin-like peptides (ILPs), which include insulin, insulin-like growth
factor 1 (IGF1) and IGF2, exert many effects in the brain. Through their actions on brain …

The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity

TE Chater, Y Goda - Frontiers in cellular neuroscience, 2014 - frontiersin.org
In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

LTP and LTD: an embarrassment of riches

RC Malenka, MF Bear - Neuron, 2004 - cell.com
LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

Synaptic plasticity: multiple forms, functions, and mechanisms

A Citri, RC Malenka - Neuropsychopharmacology, 2008 - nature.com
Experiences, whether they be learning in a classroom, a stressful event, or ingestion of a
psychoactive substance, impact the brain by modifying the activity and organization of …

Long-term depression in the CNS

GL Collingridge, S Peineau, JG Howland… - Nature reviews …, 2010 - nature.com
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a
process that may be involved in learning and memory and in various pathological …