Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration

S Lee, N Silverman, FB Gao - Trends in Neurosciences, 2024 - cell.com
Antimicrobial peptides (AMPs), a collection of small proteins with important roles in classical
innate immunity, have been extensively studied in multiple organisms, particularly in …

The role of suppressor of cytokine signaling 3 in inflammatory bowel disease and its associated colorectal cancer

P Zhang, B Pei, C Yi, FA Akanyibah, F Mao - Biochimica et Biophysica Acta …, 2024 - Elsevier
Inflammatory bowel disease (IBD) and colorectal cancer (CRC), as two of the major human
intestinal diseases, provide challenges for the medical field. Suppressor of cytokine …

Discovery of a New Anti-Inflammatory Agent from Anemoside B4 Derivatives and Its Therapeutic Effect on Colitis by Targeting Pyruvate Carboxylase

L Lv, Q Li, K Wang, J Zhao, K Deng… - Journal of Medicinal …, 2024 - ACS Publications
Anemoside B4 (AB4), a triterpenoidal saponin from Pulsatilla chinensis, shows significant
anti-inflammatory activity, and may be used for treating inflammatory bowel disease (IBD) …

Pterostilbene Alleviates Dextran Sodium Sulfate (DSS)-Induced Intestinal Barrier Dysfunction Involving Suppression of a S100A8-TLR-4-NF-κB Signaling Cascade

K Lv, J Song, J Wang, W Zhao, F Yang… - Journal of Agricultural …, 2024 - ACS Publications
Intestinal barrier hemostasis is the key to health. As a resveratrol analogue, pterostilbene
(PT) has been reported to prevent dextran sodium sulfate (DSS)-induced intestinal barrier …

Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies

A Deka, N Kumar, S Basu, M Chawla… - The EMBO …, 2024 - embopress.org
Dendritic cell (DC) dysfunction is known to exacerbate intestinal pathologies, but the
mechanisms compromising DC-mediated immune regulation in this context remain unclear …

Zinc deficiency leads to reproductive impairment in male mice through imbalance of zinc homeostasis and inflammatory response

Z Hou, J Ma, H Li, X Wang, W Li, X Liu, Y Tie… - … Trace Element Research, 2024 - Springer
Zinc is an essential trace element crucial for growth and development and plays a significant
role in male reproductive function. The aim of this study was explore the mechanism of male …

Accelerating repair of infected bone defects through post-reinforced injectable hydrogel mediated antibacterial/immunoregulatory microenvironment at bone-hydrogel …

Z Wang, Y Chu, J Du, Y Hu, H Wang, H Liu… - Carbohydrate …, 2025 - Elsevier
Functional injectable hydrogel (IH) is promising for infected bone defects (IBDs) repair, but
how to endow it with desired antibacterial/immunoregulatory functions as well as avoid …

A derivative of tanshinone IIA and salviadione, 15a, inhibits inflammation and alleviates DSS-induced colitis in mice by direct binding and inhibition of RIPK2

C Hu, Y Chen, T **, Z Wang, B **, J Liao… - Acta Pharmacologica …, 2024 - nature.com
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions primarily affecting
the gastrointestinal tract. Previous studies established the role of the NF-κB signaling …

[HTML][HTML] The Role of Environmental and Nutritional Factors in the Development of Inflammatory Bowel Diseases: A Case–Control Study

V Serrano-Fernandez, JA Laredo-Aguilera… - Nutrients, 2024 - mdpi.com
Background: The incidence and prevalence of inflammatory bowel diseases (IBD) are
increasing around the world, especially in Western countries. The objective of this study was …

Sesquiterpene lactones from Cichorium intybus exhibit potent anti-inflammatory and hepatoprotective effects by repression of NF-κB and enhancement of NRF2

Y Zhou, T Wen, S Yang, B Meng, J Wei, J Zhang… - Journal of …, 2025 - Elsevier
Ethnopharmacological relevance Cichorium intybus is a traditional medicinal herb for
hepatitis treatment in China and Europe. Sesquiterpene lactones are the main active …