Multireference approaches for excited states of molecules

H Lischka, D Nachtigallova, AJA Aquino… - Chemical …, 2018 - ACS Publications
Understanding the properties of electronically excited states is a challenging task that
becomes increasingly important for numerous applications in chemistry, molecular physics …

Theory and simulation of the ultrafast double-bond isomerization of biological chromophores

S Gozem, HL Luk, I Schapiro, M Olivucci - Chemical reviews, 2017 - ACS Publications
Ultrafast processes in light-absorbing proteins have been implicated in the primary step in
the light-to-energy conversion and the initialization of photoresponsive biological functions …

Quantum–classical simulations of rhodopsin reveal excited-state population splitting and its effects on quantum efficiency

X Yang, M Manathunga, S Gozem, J Léonard… - Nature …, 2022 - nature.com
The activation of rhodopsin, the light-sensitive G-protein-coupled receptor responsible for
dim-light vision in vertebrates, is driven by an ultrafast excited-state double-bond …

Why do some vertebrates have microchromosomes?

K Srikulnath, SF Ahmad, W Singchat, T Panthum - Cells, 2021 - mdpi.com
With more than 70,000 living species, vertebrates have a huge impact on the field of biology
and research, including karyotype evolution. One prominent aspect of many vertebrate …

Exploiting machine learning to efficiently predict multidimensional optical spectra in complex environments

MS Chen, TJ Zuehlsdorff, T Morawietz… - The Journal of …, 2020 - ACS Publications
The excited-state dynamics of chromophores in complex environments determine a range of
vital biological and energy capture processes. Time-resolved, multidimensional optical …

a-ARM: Automatic Rhodopsin Modeling with Chromophore Cavity Generation, Ionization State Selection, and External Counterion Placement

L Pedraza-González, L De Vico, MC Marı́n… - Journal of chemical …, 2019 - ACS Publications
The Automatic Rhodopsin Modeling (ARM) protocol has recently been proposed as a tool
for the fast and parallel generation of basic hybrid quantum mechanics/molecular mechanics …

[HTML][HTML] Nonlinear spectroscopy in the condensed phase: The role of Duschinsky rotations and third order cumulant contributions

TJ Zuehlsdorff, H Hong, L Shi, CM Isborn - The Journal of Chemical …, 2020 - pubs.aip.org
First-principles modeling of nonlinear optical spectra in the condensed phase is highly
challenging because both environment and vibronic interactions can play a large role in …

Bidirectional Photochemistry of Antarctic Microbial Rhodopsin: Emerging Trend of Ballistic Photoisomerization from the 13-cis Resting State

P Malakar, I Das, S Bhattacharya, A Harris… - The journal of …, 2022 - ACS Publications
The decades-long ultrafast examination of nearly a dozen microbial retinal proteins, ion
pumps, and sensory photoreceptors has not identified structure–function indicators which …

Fluorescence enhancement of a microbial rhodopsin via electronic reprogramming

MC Marin, D Agathangelou… - Journal of the …, 2018 - ACS Publications
The engineering of microbial rhodopsins with enhanced fluorescence is of great importance
in the expanding field of optogenetics. Here we report the discovery of two mutants …

QM/MM methods for free energies and photochemistry

E Boulanger, JN Harvey - Current Opinion in Structural Biology, 2018 - Elsevier
Highlights•QM/MM can be used to probe biomolecular photochemistry as well as
reactivity.•Many new free energy methods suitable for QM/MM are being developed.•QM/MM …