The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Thanks to their unique attributes, such as good sensitivity, selectivity, high surface-to-volume
ratio, and versatile optical and electronic properties, fluorescent-based bioprobes have been …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Contact lenses as a minimally invasive platform for diagnostics and drug delivery have
emerged in recent years. Contact lens sensors have been developed for analyzing the …

Soluble sugars serve five main purposes in multicellular organisms: as sources of carbon
skeletons, osmolytes, signals, and transient energy storage and as transport molecules …

Tumors have a greater reliance on anaerobic glycolysis for energy production than normal
tissues. We developed a noninvasive method for imaging glucose uptake in vivo that is …

Fluorescence resonance energy transfer (FRET) is a nonradiative process whereby an
excited state donor D (usually a fluorophore) transfers energy to a proximal ground state …

This critical review covers the present state of the art in optical sensing of glucose. Following
an introduction into the significance of (continuous) sensing of glucose and a brief look back …

Lactate is shuttled between and inside cells, playing metabolic and signaling roles in
healthy tissues. Lactate is also a harbinger of altered metabolism and participates in the …

The concept of metabolite profiling has been around for several decades, but only recent
technical innovations have allowed metabolite profiling to be carried out on a large scale …