The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Mixing in microfluidic devices and enhancement methods

K Ward, ZH Fan - Journal of Micromechanics and …, 2015 - iopscience.iop.org
Mixing in microfluidic devices presents a challenge due to laminar flows in microchannels,
which result from low Reynolds numbers determined by the channel's hydraulic diameter …

A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow

D Perera, JW Tucker, S Brahmbhatt, CJ Helal, A Chong… - Science, 2018 - science.org
The scarcity of complex intermediates in pharmaceutical research motivates the pursuit of
reaction optimization protocols on submilligram scales. We report here the development of …

Droplet based microfluidics

R Seemann, M Brinkmann, T Pfohl… - Reports on progress …, 2011 - iopscience.iop.org
Droplet based microfluidics is a rapidly growing interdisciplinary field of research combining
soft matter physics, biochemistry and microsystems engineering. Its applications range from …

Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis

RL Hartman, JP McMullen… - Angewandte Chemie …, 2011 - Wiley Online Library
The fine chemicals and pharmaceutical industries are transforming how their products are
manufactured, where economically favorable, from traditional batchwise processes to …

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications

D Mark, S Haeberle, G Roth, F Von Stetten… - Microfluidics based …, 2010 - Springer
This review summarizes recent developments in microfluidic platform approaches. In
contrast to isolated application-specific solutions, a microfluidic platform provides a set of …

Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications–a review

J Ma, SMY Lee, C Yi, CW Li - Lab on a Chip, 2017 - pubs.rsc.org
Nanoparticles have drawn significant attention in biomedicine due to their unique optical,
thermal, magnetic and electrical properties which are highly related to their size and …

The origins and the future of microfluidics

GM Whitesides - nature, 2006 - nature.com
The manipulation of fluids in channels with dimensions of tens of micrometres—microfluidics—
has emerged as a distinct new field. Microfluidics has the potential to influence subject areas …

Dynamics of microfluidic droplets

CN Baroud, F Gallaire, R Dangla - Lab on a Chip, 2010 - pubs.rsc.org
This critical review discusses the current understanding of the formation, transport, and
merging of drops in microfluidics. We focus on the physical ingredients which determine the …

Feedback in flow for accelerated reaction development

BJ Reizman, KF Jensen - Accounts of chemical research, 2016 - ACS Publications
Conspectus The pharmaceutical industry is investing in continuous flow and high-
throughput experimentation as tools for rapid process development accelerated scale-up …