Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors, with
many GPCRs having crucial roles in endocrinology and metabolism. Cryogenic electron …

Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse
symptoms, which can persist for months. While antiviral antibodies are protective, those …

Two-thirds of human hormones and one-third of clinical drugs activate~ 350 G-protein-
coupled receptors (GPCR) belonging to four classes: A, B1, C and F. Whereas a model of …

Summary Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that
activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G …

Our previous studies have showed that CC motif chemokine ligand 20 (CCL20) advanced
tumor progression and enhanced the chemoresistance of cancer cells by positively …

The complement receptors C3aR and C5aR1, whose signaling is selectively activated by
anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune …

Biased signaling of G protein-coupled receptors describes an ability of different ligands that
preferentially activate an alternative downstream signaling pathway. In this work, we …

The chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation.
However, molecular details that govern its endogenous chemokine recognition and receptor …

The chemotaxis of CD4+ type 1 helper cells and CD8+ cytotoxic lymphocytes, guided by
interferon-inducible CXC chemokine 9–11 (CXCL9–11) and CXC chemokine receptor 3 …