Targeting of hepatic macrophages by therapeutic nanoparticles

CI Colino, JM Lanao, C Gutierrez-Millan - Frontiers in immunology, 2020 - frontiersin.org
Hepatic macrophage populations include different types of cells with plastic properties that
can differentiate into diverse phenotypes to modulate their properties in response to different …

[HTML][HTML] Plant-derived nanovesicles: Further exploration of biomedical function and application potential

A Li, D Li, Y Gu, R Liu, X Tang, Y Zhao, F Qi… - … Pharmaceutica Sinica B, 2023 - Elsevier
Extracellular vesicles (EVs) are phospholipid bilayer vesicles actively secreted by cells, that
contain a variety of functional nucleic acids, proteins, and lipids, and are important mediums …

Internalization of garlic-derived nanovesicles on liver cells is triggered by interaction with CD98

H Song, BSB Canup, VL Ngo, TL Denning, P Garg… - ACS …, 2020 - ACS Publications
The mechanism of how plant-derived nanovesicles are uptaken by cells remains unknown.
In this study, the garlic-derived nanovesicles (GDVs) were isolated and digested with trypsin …

[HTML][HTML] Potential and applications of nanocarriers for efficient delivery of biopharmaceuticals

A Zeb, I Rana, HI Choi, CH Lee, SW Baek, CW Lim… - Pharmaceutics, 2020 - mdpi.com
During the past two decades, the clinical use of biopharmaceutical products has markedly
increased because of their obvious advantages over conventional small-molecule drug …

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State‐of‐the‐Art Review

SA Moosavian, T Sathyapalan… - Bioinorganic …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to
end‐stage liver disease needing a liver transplant. Many pharmacological approaches are …

Factors affecting the clearance and biodistribution of polymeric nanoparticles

K Parmar, J Patel, Y Pathak - Pharmacokinetics and Pharmacodynamics of …, 2022 - Springer
Nanoparticles are promising drug delivery for various therapeutic applications.
Pharmacokinetics is important to study the in vivo fate of nanoparticles. Biodistribution and …

Delivery of microRNA-33 antagomirs by mesoporous silica nanoparticles to ameliorate lipid metabolic disorders

Y Tao, S Xu, J Wang, L Xu, C Zhang, K Chen… - Frontiers in …, 2020 - frontiersin.org
Lipid metabolic disorders have become a major global public health concern. Fatty liver and
dyslipidemia are major manifestations of these disorders. Recently, MicroRNA-33 (miR-33) …

[HTML][HTML] Digoxin mitigates diethylnitrosamine-induced acute liver injury in mice via limiting production of inflammatory mediators

ME Shaker, MF Hamed, AA Shaaban - Saudi Pharmaceutical Journal, 2022 - Elsevier
The cardiotonic digoxin has been recently shown to possess an anti-inflammatory potential
in numerous metabolic and inflammatory disorders. However, data about digoxin's impact in …

Doxorubicin Intracellular Release Via External UV Irradiation of Dextran-g-poly(o-nitrobenzyl acrylate) Photosensitive Nanoparticles

M El Founi, H Laroui, BSB Canup… - ACS Applied Bio …, 2021 - ACS Publications
In the present study, innovative doxorubicin-loaded nanoparticles (NPs) made of a
photosensitive poly (o-nitrobenzyl acrylate)(PNBA) hydrophobic matrix and an hydrophilic …

Nano-drug delivery systems (NDDS) in metabolic dysfunction-associated steatotic liver disease (MASLD): current status, prospects and challenges

Y Yang, X Wang - Frontiers in Pharmacology, 2024 - frontiersin.org
About one-third of the global population suffers from metabolic dysfunction-associated
steatotic liver disease (MASLD), but specific treatments for MASLD have long been lacking …