The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

The Wnt signaling pathway plays a key role in several biological processes, such as cellular
proliferation and tissue regeneration, and its dysregulation is involved in the pathogenesis of …

Bone defects affect the daily activities of patients and are prevalent complications of various
skeletal disorders. The miR29 family regulates bone physiology and pathological processes …

Abstract Circular RNA FOXO3 (CircFOXO3, also termed as Hsa_circ_0006404) is derived
from exon 2 of forkhead box O3 (FOXO3) gene, and abnormal expression is shown in …

Osteoporosis is a major concern worldwide and can be attributed to an imbalance between
osteoblastic bone formation and osteoclastic bone resorption due to the natural aging …

Imbalance of bone homeostasis, with excessive bone resorption compared with bone
formation, leads to the development of progressive osteopenia leading to lower bone …

Hundreds of trillions of bacteria are present in the human body in a mutually beneficial
symbiotic relationship with the host. A stable dynamic equilibrium exists in healthy …

Osteoporosis (OP) is defined by bone mass loss and structural bone deterioration. Currently,
there are no effective therapies for OP treatment. Circular RNAs (circRNAs) have been …

MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-
coding RNA molecules whose main function is the post-transcriptional regulation of gene …

During the last few decades, it has been established that messenger ribonucleic acid
(mRNA) transcription does not inevitably lead to protein translation, but there are numerous …