Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

Living in an oxygenated environment has required the evolution of effective cellular
strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen …

▪ Abstract Molecular chaperones, including the heat-shock proteins (Hsps), are a ubiquitous
feature of cells in which these proteins cope with stress-induced denaturation of other …

Most heat shock proteins (Hsp) function as molecular chaperones that help organisms to
cope with stress of both an internal and external nature. Here, we review the recent …

▪ Abstract The functional causes of life history trade-offs have been a topic of interest to
evolutionary biologists for over six decades. Our review of life history trade-offs discusses …

The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock
response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and …

Although adaptation of Drosophila to thermal extremes has been investigated for many
years, only recently has much progress been made in identifying the genetic and …

Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and
rodents. In the nematode and the fly, secondary hormones downstream of insulin-like …

The heat shock proteins (HSPs) induced by cell stress are expressed at high levels in a wide
range of tumors and are closely associated with a poor prognosis and resistance to therapy …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. A progressive deterioration in the ability of cells to preserve the …