BACKGROUND Knowledge of the proteomic composition of the gametes is essential to
understand reproductive functions. Most of the sperm proteins are related to …

The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

The 26S proteasome is the main protease in eukaryotes. Proteolysis occurs within the
cylindrical 20S proteasome that is constitutively expressed in most tissues. However, three …

In mammals, transit through the epididymis, which involves the acquisition, loss and
modification of proteins, is required to confer motility and fertilization competency to sperm …

Mammalian sperm must spend a minimum period of time within a female reproductive tract
to achieve the capacity to fertilize oocytes. This phenomenon, termed sperm 'capacitation' …

The increasing use of “-omics”(genomic, transcriptomic, proteomic, epigenomic, and
metabolomic) high-throughput measurement technologies over the past decade is …

Quantitative proteomic studies are contributing greatly to the understanding of the
spermatozoon through the provision of detailed information on the proteins spermatozoa …

Protein degradation mediated by the proteasome is important for the protein homeostasis.
Various proteasome activators, such as PA28 and PA200, regulate the proteasome function …

Seminal fluid proteins (SFPs) mediate an array of postmating reproductive processes that
influence fertilization and fertility. As such, it is widely held that SFPs may contribute to …

Proteins are essential for sperm function, including their fertilizing capacity. Pig
spermatozoa, emitted in well-defined ejaculate fractions, vary in their functionality, which …