UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Over 8000 different flavonoids have been described and a considerable number of new
flavonoid structures are being elucidated every year. The advent of metabolomics alongside …

Submergence stress represents a major obstacle limiting the application of direct seeding in
rice cultivation. Under flooding conditions, coleoptile elongation can function as an escape …

The phenylpropanoid pathway in plants is responsible for the biosynthesis of a huge amount
of secondary metabolites derived from phenylalanine and tyrosine. Both flavonoids and …

Saponins are bioactive compounds generally considered to be produced by plants to
counteract pathogens and herbivores. Besides their role in plant defense, saponins are of …

Decoration of phytochemicals contributes to the majority of metabolic diversity in nature,
whereas how this process alters the biological functions of their precursor molecules …

Microbiome-encoded β-glucuronidase (GUS) enzymes play important roles in human health
by metabolizing drugs in the gastrointestinal (GI) tract. The numbers, types, and diversity of …

Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and
detoxification of xenobiotics and drugs introduced into the human body. Most of the tissues …

Summary The 2–oxoglutarate‐dependent dioxygenase (2 OGD) superfamily is the second
largest enzyme family in the plant genome, and its members are involved in various …

In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …