Cavitary tuberculosis: the gateway of disease transmission

ME Urbanowski, AA Ordonez… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …

History of pulmonary tuberculosis

AT Pezzella - Thoracic surgery clinics, 2019 - thoracic.theclinics.com
History of Pulmonary Tuberculosis - Thoracic Surgery Clinics Skip to Main Content
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A mathematical study of a tuberculosis model with fractional derivatives

H Abboubakar, P Kumar, VS Erturk… - International Journal of …, 2021 - World Scientific
In this work, we use a Predictor–Corrector method to implement and derive an iterative
solution of an existing Tuberculosis (TB) model with two fractional derivatives, namely …

In vitro drug discovery models for Mycobacterium tuberculosis relevant for host infection

T Parish - Expert opinion on drug discovery, 2020 - Taylor & Francis
Introduction: Tuberculosis is the leading cause of death from infectious disease. Current
drug therapy requires a combination of antibiotics taken over> 6 months. An urgent need for …

A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment

D Kirschner, E Pienaar, S Marino… - Current opinion in systems …, 2017 - Elsevier
Tuberculosis (TB) is an ancient and deadly disease characterized by complex host-
pathogen dynamics playing out over multiple time and length scales and physiological …

M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments

NP Kalia, S Singh, K Hards, CY Cheung, E Sviriaeva… - Cell Reports, 2023 - cell.com
The bioenergetic mechanisms by which Mycobacterium tuberculosis survives hypoxia are
poorly understood. Current models assume that the bacterium shifts to an alternate electron …

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

N Pereira de Sa, A Taouil, J Kim, T Clement… - Nature …, 2021 - nature.com
Pathogenic fungi exhibit a heavy burden on medical care and new therapies are needed.
Here, we develop the fungal specific enzyme sterylglucosidase 1 (Sgl1) as a therapeutic …

Development and analysis of multiscale models for tuberculosis: from molecules to populations

P Nanda, M Budak, CT Michael, K Krupinsky… - Predicting Pandemics in …, 2024 - Springer
Although infectious disease dynamics are often analyzed at the macroscale, increasing
numbers of drug-resistant infections highlight the importance of within-host modeling that …

Phenotypic adaptation of Mycobacterium tuberculosis to host-associated stressors that induce persister formation

T Parbhoo, JM Mouton, SL Sampson - Frontiers in Cellular and …, 2022 - frontiersin.org
Mycobacterium tuberculosis exhibits a remarkable ability to interfere with the host
antimicrobial response. The pathogen exploits elaborate strategies to cope with diverse host …

Mesenchymal stem cells and tuberculosis: Clinical challenges and opportunities

X Zhang, Q **e, Z Ye, Y Li, Z Che, M Huang… - Frontiers in …, 2021 - frontiersin.org
Tuberculosis (TB) is one of the communicable diseases caused by Mycobacterium
tuberculosis (Mtb) infection, affecting nearly one-third of the world's population. However …