Large amounts of adenosine triphosphate (ATP), a natural P2X7 receptor activator, are
released during colorectal carcinogenesis. P2X7 receptor activation regulates the activity of …

The Eph/ephrin system regulates many developmental processes and adult tissue
homeostasis. In colorectal cancer (CRC), it is involved in different processes including …

The ephrin type‐A 2 receptor tyrosine kinase (EPHA2) is involved in the development and
progression of various cancer types, including colorectal cancer (CRC). There is also …

Pyrimidine‐based derivatives have attracted a lot of interest in heterocyclic chemistry due to
its versatile structure and diverse biological activities. This study provides a comprehensive …

Applying artificial intelligence techniques to flexibly model the binding between the ligand
and protein has attracted extensive interest in recent years, but their applicability remains …

Studies trying to understand cell death, this ultimate biological process, can be traced back
to a century ago. Yet, unlike many other fashionable research interests, research on cell …

Protein kinases are prime targets for drug development due to their involvement in various
cancers. However, selective inhibition of kinases, while avoiding off-target effects remains a …