Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous
developmental genes. To silence or activate gene expression, respectively, PcG and trxG …

Developmental enhancers initiate transcription and are fundamental to our understanding of
developmental networks, evolution and disease. Despite their importance, the properties …

How polycomb group proteins repress gene expression in vivo is not known. While histone-
modifying activities of the polycomb repressive complexes (PRCs) have been studied …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

Assembly, mobilization and disassembly of nucleosomes can influence the regulation of
gene expression and other processes that act on eukaryotic DNA. Distinct nucleosome …

Polycomb/Trithorax group response elements (PRE/TREs) are fascinating chromosomal
pieces. Just a few hundred base pairs long, these elements can remember and maintain the …

The family of Hox genes, which number 4 to 48 per genome depending on the animal,
control morphologies on the main body axis of nearly all metazoans. The conventional …

The control of gene expression involves regulatory elements that can be very far from the
genes they control. Several recent technological advances have allowed the direct detection …

In Drosophila, the function of the Polycomb group genes (PcGs) and their target sequences
(Polycomb response elements (PREs)) is to convey mitotic heritability of transcription …