[HTML][HTML] Bacteria and bacterial derivatives as delivery carriers for immunotherapy

SR Kang, DH Nguyen, SW Yoo, JJ Min - Advanced Drug Delivery Reviews, 2022 - Elsevier
There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

Biomimetic hybrid membrane-based nanoplatforms: synthesis, properties and biomedical applications

Y Liao, Y Zhang, NT Blum, J Lin, P Huang - Nanoscale Horizons, 2020 - pubs.rsc.org
The rapid clearance and capture by the immune system pose a big challenge in targeted
drug delivery using nanocarriers. Cell membrane coating endows nanoplatforms with …

Bioengineered cellular and cell membrane-derived vehicles for actively targeted drug delivery: so near and yet so far

MY Thanuja, C Anupama, SH Ranganath - Advanced drug delivery reviews, 2018 - Elsevier
Cellular carriers for drug delivery are attractive alternatives to synthetic nanoparticles owing
to their innate homing/targeting abilities. Here, we review molecular interactions involved in …

Carcinogenesis and therapeutics: the microbiota perspective

MCB Tsilimigras, A Fodor, C Jobin - Nature microbiology, 2017 - nature.com
Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells
over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers …

Microbes as medicines: harnessing the power of bacteria in advancing cancer treatment

SS Sawant, SM Patil, V Gupta, NK Kunda - International journal of …, 2020 - mdpi.com
Conventional anti-cancer therapy involves the use of chemical chemotherapeutics and
radiation and are often non-specific in action. The development of drug resistance and the …

Bacteria‐mediated tumor therapy via photothermally‐programmed cytolysin a expression

L Wang, W Qin, W Xu, F Huang, X **e, F Wang, L Ma… - Small, 2021 - Wiley Online Library
By leveraging the ability of bacteria to express therapeutic protein cytolysin A (ClyA) through
plasmid transformation, a thermally‐activated biohybrid (TAB@ Au) is constructed by …

16S rRNA gene primer choice impacts off-target amplification in human gastrointestinal tract biopsies and microbiome profiling

T Deissová, M Zapletalová, L Kunovský, R Kroupa… - Scientific Reports, 2023 - nature.com
Abstract 16S rRNA amplicon sequencing or, more recently, metatranscriptomic analysis are
currently the only preferred methods for microbial profiling of samples containing a …

In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy

CJ Chiang, YH Hong - Scientific Reports, 2021 - nature.com
Butyrate has a bioactive function to reduce carcinogenesis. To achieve targeted cancer
therapy, this study developed bacterial cancer therapy (BCT) with butyrate as a payload. By …

Advances in bacterial cancer therapies using synthetic biology

T Chien, A Doshi, T Danino - Current opinion in systems biology, 2017 - Elsevier
Synthetic biology aims to apply engineering principles to biology by modulating the behavior
of living organisms. An emerging application of this field is the engineering of bacteria as a …

The prospects for the therapeutic implications of genetically engineered probiotics

SF Mazhar, M Afzal, A Almatroudi, S Munir… - Journal of Food …, 2020 - Wiley Online Library
The interest in the therapeutic use of probiotic microorganisms has been increased during
the last decade although the doubts have ascended about the probiotics mainly because …