[HTML][HTML] Schizophrenia, dopamine and the striatum: from biology to symptoms
The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …
[HTML][HTML] Acetylcholine bidirectionally regulates learning and memory
Q Huang, C Liao, F Ge, J Ao, T Liu - Journal of Neurorestoratology, 2022 - Elsevier
Acetylcholine (ACh) is one of the most important neurotransmitters in the central cholinergic
system; it specifically binds to muscarinic and nicotinic receptors and is degraded by …
system; it specifically binds to muscarinic and nicotinic receptors and is degraded by …
[HTML][HTML] Connecting circuits for supraspinal control of locomotion
MJ Ferreira-Pinto, L Ruder, P Capelli, S Arber - Neuron, 2018 - cell.com
Locomotion is regulated by distributed circuits and achieved by the concerted activation of
body musculature. While the basic properties of executive circuits in the spinal cord are fairly …
body musculature. While the basic properties of executive circuits in the spinal cord are fairly …
Targeting muscarinic acetylcholine receptors for the treatment of psychiatric and neurological disorders
Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …
behaviors such as cognition, movement, and reward, making them ideally situated as …
Targeting muscarinic receptors to treat schizophrenia
Schizophrenia is a severe neuropsychiatric disorder characterized by a diverse range of
symptoms that can have profound impacts on the lives of patients. Currently available …
symptoms that can have profound impacts on the lives of patients. Currently available …
Fine tuning muscarinic acetylcholine receptor signaling through allostery and bias
The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …
A non-canonical striatopallidal Go pathway that supports motor control
In the classical model of the basal ganglia, direct pathway striatal projection neurons
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …
Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA–induced dyskinetic behaviors
BE Nielsen, CP Ford - Science Advances, 2024 - science.org
A dynamic equilibrium between dopamine and acetylcholine (ACh) is essential for striatal
circuitry and motor function, as imbalances are associated with Parkinson's disease (PD) …
circuitry and motor function, as imbalances are associated with Parkinson's disease (PD) …
The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson's disease
The pedunculopontine nucleus (PPN) is the major part of the mesencephalic locomotor
region, involved in the control of gait and locomotion. The PPN contains glutamatergic …
region, involved in the control of gait and locomotion. The PPN contains glutamatergic …
Circuits for state-dependent modulation of locomotion
Brain-wide neural circuits enable bi-and quadrupeds to express adaptive locomotor
behaviors in a context-and state-dependent manner, eg, in response to threats or rewards …
behaviors in a context-and state-dependent manner, eg, in response to threats or rewards …