Sepsis is defined as an exaggerated, systemic inflammatory response to infection and is a
common condition in horses. Systemic inflammatory response syndrome (SIRS) associated …

Introduction Gram-negative bacterial infections represent still a severe problem of human
health care, regarding the increase in multi-resistance against classical antibiotics and the …

Enteroid cultures are three-dimensional in vitro models that reflect the cellular composition
and architecture of the small intestine. One limitation with the enteroid conformation is the …

Inflammatory bowel disease (IBD) in horses is an idiopathic disorder, encompassing
different types of chronic intestinal inflammation. The pathogenesis of the disease remains to …

The microbiota and its metabolites play an important role in regulating the host metabolism
and immunity. However, the underlying mechanism is still not well studied. Thus, we …

Background Local inflammation may progress into systemic inflammation. To increase our
understanding of the basic immunological processes during transition of equine local …

Background In horses, insights into the innate immune processes in acute systemic
inflammation are limited even though these processes may be highly important for future …

There is accumulating evidence for the involvement of pro-inflammatory cytokines
associated with a T helper 17 response in intestinal disorders such as inflammatory bowel …

Accumulating high-speed exercise has been identified as a significant risk factor for
catastrophic injuries in racing Thoroughbreds. Injuries, regardless of severity, are a main …

Background: The kidney is one of the prior damaged organs subjected to severe infection
and sepsis shock. Our previous studies have shown that the normal mesenteric lymph …