An important development in understanding the influence of chromatin on gene regulation
has been the finding that DNA methylation and histone post-translational modifications lead …

Histone acetylation regulates many cellular processes, and specific acetylation marks, either
singly or in combination, produce distinct outcomes. For example, the acetylation pattern on …

Ageing results from complex genetically and epigenetically programmed processes that are
elicited in part by noxious or stressful events that cause programmed cell death. Here, we …

Covalent modifications of the amino termini of the core histones in nucleosomes have
important roles in gene regulation. Research in the past two years reveals these …

Previous in vitro studies showed that the bromodomain binds to acetyllysines on histone
tails, leading to the proposal that the domain is involved in deciphering the histone code …

Gene activation and repression regulated by acetylation and deacetylation represent a
paradigm for the function of histone modifications. We provide evidence that, in contrast …

Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in
gene regulation,,–. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation …

In S. cerevisiae, histone variant H2A. Z is deposited in euchromatin at the flanks of silent
heterochromatin to prevent its ectopic spread. We show that H2A. Z nucleosomes are found …

Although histone acetylation has historically been linked to transcription activation, recent
studies indicate that this modification and the enzymes that catalyze it have much broader …

Members of the ING family of tumor suppressors regulate cell cycle progression, apoptosis,
and DNA repair as important cofactors of p53. ING1 and ING3 are stable components of the …