Precision drug delivery to the central nervous system using engineered nanoparticles
J Gao, Z ** of Drosophila
The fruit fly Drosophila melanogaster has emerged as a key model organism in
neuroscience, in large part due to the concentration of collaboratively generated molecular …
neuroscience, in large part due to the concentration of collaboratively generated molecular …
Molecularly defined and spatially resolved cell atlas of the whole mouse brain
In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …
a wide range of functions. The enormous diversity and intricate organization of cells have …
[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
Custom microfluidic chip design enables cost-effective three-dimensional spatiotemporal transcriptomics with a wide field of view
Spatial transcriptomic techniques offer unprecedented insights into the molecular
organization of complex tissues. However, integrating cost-effectiveness, high throughput, a …
organization of complex tissues. However, integrating cost-effectiveness, high throughput, a …
Functional connectomics spanning multiple areas of mouse visual cortex
MICrONS Consortium, JA Bae, M Baptiste, CA Bishop… - BioRxiv, 2021 - biorxiv.org
To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …
architecture that shapes them. Here, we present a large functional connectomics dataset …
Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain
Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
Single-cell analysis of chromatin accessibility in the adult mouse brain
Recent advances in single-cell technologies have led to the discovery of thousands of brain
cell types; however, our understanding of the gene regulatory programs in these cell types is …
cell types; however, our understanding of the gene regulatory programs in these cell types is …
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer
E Buglakova, M Ekelöf, M Schwaiger-Haber… - Nature …, 2024 - nature.com
While heterogeneity is a key feature of cancer, understanding metabolic heterogeneity at the
single-cell level remains a challenge. Here we present 13C-SpaceM, a method for spatial …
single-cell level remains a challenge. Here we present 13C-SpaceM, a method for spatial …