Rationally engineered nucleic acid architectures for biosensing applications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …
MicroRNA: function, detection, and bioanalysis
Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution
MN Cabili, MC Dunagin, PD McClanahan, A Biaesch… - Genome biology, 2015 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) have been implicated in diverse
biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far …
biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far …
Toehold‐initiated rolling circle amplification for visualizing individual microRNAs in situ in single cells
The ability to quantitate and visualize microRNAs (miRNAs) in situ in single cells would
greatly facilitate the elucidation of miRNA‐mediated regulatory circuits and their disease …
greatly facilitate the elucidation of miRNA‐mediated regulatory circuits and their disease …
Application of atomic force microscopy in cancer research
Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and
molecules. Recent advances have enabled its application in cancer research and diagnosis …
molecules. Recent advances have enabled its application in cancer research and diagnosis …
[HTML][HTML] A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells
Summary microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …
MicroRNA array analysis finds elevated serum miR-1290 accurately distinguishes patients with low-stage pancreatic cancer from healthy and disease controls
Purpose: Our goal was to identify circulating micro RNA (miRNA) levels that could
distinguish patients with low-stage pancreatic cancer from healthy and disease controls …
distinguish patients with low-stage pancreatic cancer from healthy and disease controls …
miR‐155 modulates microglia‐mediated immune response by down‐regulating SOCS‐1 and promoting cytokine and nitric oxide production
Innate immunity constitutes the first line of defence against both external and endogenous
threats in the brain, and microglia cells are considered key mediators of this process. Recent …
threats in the brain, and microglia cells are considered key mediators of this process. Recent …
Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
N Wang, J Zheng, Z Chen, Y Liu, B Dura… - Nature …, 2019 - nature.com
Measuring multiple omics profiles from the same single cell opens up the opportunity to
decode molecular regulation that underlies intercellular heterogeneity in development and …
decode molecular regulation that underlies intercellular heterogeneity in development and …
ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification
Methods for detecting single nucleic acids in cell and tissues, such as fluorescence in situ
hybridization (FISH), are limited by relatively low signal intensity and nonspecific probe …
hybridization (FISH), are limited by relatively low signal intensity and nonspecific probe …