WHIM syndrome is a rare combined primary immunodeficiency disease named by acronym
for the diagnostic tetrad of warts, hypogammaglobulinemia, infections, and myelokathexis …

CXCR4 is expressed on leukaemia cells and haematopoietic stem cells (HSCs), and its
ligand stromal‐derived factor 1 (SDF‐1) is produced abundantly by stromal cells in the bone …

CXCR 4 is a G‐protein‐coupled receptor that mediates recruitment of blood cells toward its
ligand SDF‐1. In cancer, high CXCR 4 expression is frequently associated with tumor …

Chemokine ligand-receptor interactions play a pivotal role in cell attraction and cellular
trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor …

Short lipidated peptide sequences derived from various intracellular loop regions of G
protein-coupled receptors (GPCRs) are named pepducins and act as allosteric modulators …

AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing
hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 …

A single subcutaneous (SC) injection of plerixafor results in rapid mobilization of
hematopoietic progenitors, but fails to mobilize 33% of normal allogeneic sibling donors in 1 …

Achieving successful hematopoietic stem cell transplantation (HSCT) relies on two
fundamental pillars: effective mobilization and efficient collection through apheresis to attain …

Background: Acute myocardial infarction (MI) elicits an inflammatory response that drives
tissue repair and adverse cardiac remodeling. Inflammatory cell trafficking after MI is …

Background Leukocyte subtypes bear distinct pro-inflammatory, reparative, and regulatory
functions. Imaging inflammation provides information on disease prognosis and may guide …