Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly …
ZL Zang, YX Wang, N Battini, WW Gao… - European Journal of …, 2024 - Elsevier
The global microbial resistance is a serious threat to human health, and multitargeting
compounds are considered to be promising to combat microbial resistance. In this work, a …
compounds are considered to be promising to combat microbial resistance. In this work, a …
Insights into the DNA and RNA Interactions of Human Topoisomerase III Beta Using Molecular Dynamics Simulations
Human topoisomerase III beta (hTOP3B) is the only topoisomerase in the human cell that
can act on both DNA and RNA substrates. Recent findings have emphasized the …
can act on both DNA and RNA substrates. Recent findings have emphasized the …
Type IA topoisomerases as targets for infectious disease treatments
Infectious diseases are one of the main causes of death all over the world, with antimicrobial
resistance presenting a great challenge. New antibiotics need to be developed to provide …
resistance presenting a great challenge. New antibiotics need to be developed to provide …
SPRD: a surface plasmon resonance database of common factors for better experimental planning
PB Tiwari, C Bencheqroun, M Lemus, T Shaw… - BMC molecular and cell …, 2021 - Springer
Background Surface plasmon resonance is a label-free biophysical technique that is widely
used in investigating biomolecular interactions, including protein-protein, protein-DNA, and …
used in investigating biomolecular interactions, including protein-protein, protein-DNA, and …
[HTML][HTML] Small Molecule Inhibitors of Mycobacterium tuberculosis Topoisomerase I Identified by Machine Learning and In Vitro Assays
Tuberculosis (TB) caused by Mycobacterium tuberculosis is a leading infectious cause of
death globally. The treatment of patients becomes much more difficult for the increasingly …
death globally. The treatment of patients becomes much more difficult for the increasingly …
Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens
Type IA topoisomerases maintain DNA topology by cleaving ssDNA and relaxing negative
supercoils. The inhibition of its activity in bacteria prevents the relaxation of negative …
supercoils. The inhibition of its activity in bacteria prevents the relaxation of negative …
Structural insights into the repair mechanism of AGT for methyl-induced DNA damage
Methylation induced DNA base-pairing damage is one of the major causes of cancer. O6-
alkylguanine-DNA alkyltransferase (AGT) is considered a demethylation agent of the …
alkylguanine-DNA alkyltransferase (AGT) is considered a demethylation agent of the …
Characterization of molecular interactions between HDAC7 and MEF2A
Interactions of transcriptional corepressors such as histone deacetylase 7 (HDAC7), a class
IIa HDAC, with myocyte enhancer factor-2 (MEF2) regulate MEF2 activity. Despite previous …
IIa HDAC, with myocyte enhancer factor-2 (MEF2) regulate MEF2 activity. Despite previous …
Antimycobacterial, antibiofilm and efflux pump inhibitory activity of extracts from selected Combretum species used in traditional medicine in Zimbabwe
Non-tuberculous mycobacteria infect mostly immunocompromised people. NTM infections
incidence and prevalence increase has led to a public health problem. Combretum species …
incidence and prevalence increase has led to a public health problem. Combretum species …
[HTML][HTML] A Yeast-Based Screening System for Differential Identification of Poisons and Suppressors of Human Topoisomerase I
A Seddek, C Madeira, T Annamalai… - Frontiers in Bioscience …, 2022 - imrpress.com
Background: Inhibition of human topoisomerase I (TOP1) by camptothecin and topotecan
has been shown to reduce excessive transcription of PAMP (Pathogen-Associated …
has been shown to reduce excessive transcription of PAMP (Pathogen-Associated …